Odanacatib: the best osteoporosis treatment we never had?
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چکیده
منابع مشابه
Potential role of odanacatib in the treatment of osteoporosis
Cathepsin K is a key enzyme involved in the degradation of organic bone matrix by osteoclasts. Inhibition of bone resorption observed in human and animal models deficient for cathepsin K has identified this enzyme as a suitable target for intervention by small molecules with the potential to be used as therapeutic agents in the treatment of osteoporosis. Odanacatib (ODN) is a nonbasic selective...
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Osteoclasts are specialized cells that initiate the process of bone resorption, which has two phases, dissolution of the mineral component and degradation of the organic matrix, in which cathepsin K plays a key role. Cathepsin K inhibitors, which block the activity of cathepsin on bone resorption lacunae, may be a new therapeutic option in osteoporosis. Odanacatib is a nonpeptidic biaryl inhibi...
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Throughout life, bone remodeling maintains the structure of bone tissue, leading to changes in bone density, shape and strength that allow it to adapt to biomechanical circumstances at any given time. This remodeling occurs both in cortical bone, which is responsible for load bearing, and in trabecular bone, which participates in the regulation of mineral homeostasis and bone strength. Bone rem...
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ژورنال
عنوان ژورنال: The Lancet Diabetes & Endocrinology
سال: 2019
ISSN: 2213-8587
DOI: 10.1016/s2213-8587(19)30348-1